WebMar 11, 2024 · In conclusion, the present study substantiated that quercetin induces pro-apoptotic autophagy via SIRT1/AMPK signaling pathway in non-small-cell lung cancer cell lines in vitro. Furthermore, our study might provide a more effective therapeutic strategy for lung cancer by a combination treatment with quercetin and autophagy agonist. WebApr 11, 2024 · In this study, we report that the activation of AMP-activated protein kinase (AMPK) by AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) inhibited the LNCaP and VCaP cells growth by silencing TPD52 expression. Activation of AMPK inhibited the proliferation and migration of LNCaP and VCaP cells.
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WebAug 17, 2024 · The resistance to apoptotic cell death is commonly found in tumor pathogenesis in association with deregulation of cell death and/or prosurvival signaling … WebOct 21, 2024 · Prognostic Implication of pAMPK Immunohistochemical Staining by Subcellular Location and Its Association with SMAD Protein Expression in Clear Cell Renal Cell Carcinoma Authors Minsun Jung 1 , Jeong Hoon Lee 2 , Cheol Lee 3 , Jeong Hwan Park 4 , Yu Rang Park 5 , Kyung Chul Moon 6 7 Affiliations gtx overclock software
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WebApr 16, 2024 · We next monitored expression and/or phosphorylation of cell-signaling markers in lymphomas, compared with normal thymocytes from age-matched controls. ... As expected, the levels of Thr172 phosphorylation (pAMPK) and AMPK-α expression were reduced by around 50% in the AMPK heterozygote (although the pAMPK:AMPK-α ratio … WebApr 2, 2024 · Increasing pAMPK levels and, consequently, downstream AMPK signaling pharmacologically attenuate anxiety-like behavior following nicotine withdrawal. We show that metformin, a known AMPK activator in the periphery, reduces withdrawal symptoms through a mechanism dependent on the presence of the AMPKα subunits within the … WebOct 4, 2024 · AMPK KO Jurkat cell lysates were the source of cellular protein in these experiments (endogenous pAMPK is undetectable in 10ug cellular protein from Cas9 … gtx overclocking software