WebJun 1, 2008 · RNA dynamics: it is about time. Many recently discovered RNA functions rely on highly complex multistep conformational transitions that occur in response to an array of cellular signals. These dynamics accompany and guide, for example, RNA cotranscriptional folding, ligand sensing and signaling, site-specific catalysis in … http://herschlaglab.stanford.edu/rna-folding

RNA Folding - an overview ScienceDirect Topics

WebAbstract. RNA folding and binding reactions are mediated by interactions with ions that make up the surrounding aqueous electrolytic milieu. Although Mg2+ ions are often … WebMay 2, 2008 · We develop a simplified RNA model for discrete molecular dynamics (DMD) simulations, incorporating base-pairing and base-stacking interactions. We demonstrate correct folding of 150 structurally diverse RNA sequences. The majority of DMD-predicted 3D structures have <4 A deviations from experimental structures. candy church

Monitoring RNA dynamics in native transcriptional …

WebFeb 1, 2024 · RNA folding begins as the transcript is synthesized by RNA polymerase II ... Mustoe, A. M. & Al-Hashimi, H. M. Functional complexity and regulation through RNA dynamics. Nature 482, 322–330 (2012). WebOct 1, 2009 · 2.1.. RNA folding is slow compared to intramolecular motionThe clear separation of time scales between the folding dynamics of nucleic acid (>10 μs) and the rapid intramolecular thermal motion (<0.1 μs) and heat diffusion at these scales (<10 −3 μs for a heat diffusion coefficient of about 10 −7 m 2 /s) can be directly used to control the … WebRNA Folding and Dynamics Ribozymes are excellent models for RNA folding mechanisms. We are studying the folding pathways of group I ribozymes using a combination of biochemical and physical methods … fish tank toronto