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Inhibition of curli assembly and - PNAS
WebCurli provide a unique system to study macromolecular assembly in bacteria and in vivo amyloid fiber formation. Here, we review curli biogenesis, regulation, role in biofilm formation, and role in pathogenesis. Keywords amyloid, cellulose, enteric, biofilm, extracellular matrix WebOct 30, 2024 · Curli production is dependent on the curli-specific gene (csg) operons, which encode the major structural components and accessory proteins (15–18).The major subunit of the curli amyloid fiber, CsgA, is synthesized in the cytoplasm and transported to the cell surface as an unfolded protein, where it assembles to form extracellular amyloid … tap protein function
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