Chromopyrrolic acid
Web3- (3-Indolyl)-2-oxopropanoic acid, 3-Indolylpyruvic acid. Empirical Formula (Hill Notation): C11H9NO3. CAS Number: 392-12-1. Molecular Weight: 203.19. Beilstein: 172966. WebMay 20, 2009 · Chromopyrrolic acid (CPA) oxidation by cytochrome P450 StaP is a key process in the biosynthesis of antitumor drugs (Onaka, H.; Taniguchi, S.; Igarashi, Y.; …
Chromopyrrolic acid
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WebApr 16, 2009 · Figure 1. Chromatogram showing baseline resolution of the 13 alcohols in the order listed in Table 1. Chromatographic conditions: 6 ft (∼180 cm)×2 mm ID glass … WebStaP on its own converts chromopyrrolic acid into three aglycone products, K252c, arcyriaflavin A, and 7-hydroxy-K252c; in the presence of StaC, K252c is the predominant product, while the presence of RebC directs formation of arcyriaflavin A. 18 O-Labeling studies indicate that the oxygen(s) of the pyrrolinone and maleimide functionalities of ...
WebFeb 6, 2013 · Howard-Jones, A.R.; Walsh, C.T. Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD. Biochemistry 2005, 44, 15652–15663. [Google Scholar] Onaka, H. Biosynthesis of indolocarbazole and goadsporin, two different heterocyclic antibiotics produced by … WebStaP on its own converts chromopyrrolic acid into three aglycone products, K252c, arcyriaflavin A, and 7-hydroxy-K252c; in the presence of StaC, K252c is the predominant …
WebJan 1, 2014 · Although most P450s catalyze monooxygenation reactions, there are some exceptions. One example is P450 StaP, which is a key enzyme for forming the core structure of an anticancer agent, indolocarbazole, which catalyzes the intramolecular C–C bond formation in chromopyrrolic acid (CPA). Web≥97% Synonym (s): 3- (3-Indolyl)-2-oxopropanoic acid, 3-Indolylpyruvic acid Empirical Formula (Hill Notation): C11H9NO3 CAS Number: 392-12-1 Molecular Weight: 203.19 Beilstein: 172966 EC Number: 206-874-1 …
WebIndole-3-pyruvic acid can be used: As a precursor for the synthesis of chromopyrrolic acid by a heme-containing enzyme.As a reactant in the Biginelli-like scaffold syntheses. Packaging. 1, 5 g in poly bottle. Linkage. α-Keto analogue …
WebJun 12, 2014 · The chemical structure was determined to be 3,4.di.(3-indolyl)-pyrrole 2,5-dicarboxylic acid on the bases of 1 H- and 13 C-NMR spectra, and MS data. This compound was named chromopyrrolic acid, and was also detected in the various metabolites produced by the parent strain, although the amount produced was somewhat smaller. shannon hayes buescherWebSep 25, 2007 · The biosynthesis of rebeccamycin, an antitumor compound, involves the remarkable eight-electron oxidation of chlorinated chromopyrrolic acid. Although one rebeccamycin biosynthetic enzyme is capable of generating low levels of the eight-electron oxidation product on its own, a second protein, RebC, is required to accelerate product … shannon hayes buenaflorWebJan 1, 2006 · Chromopyrrolic acid is oxidized by six electrons compared to the starting pair of L-tryptophan molecules. RebO is an L-tryptophan oxidase flavoprotein and RebD … shannon hayes turlockWebApr 5, 2012 · The indolocarbazole biosynthetic enzymes StaC, InkE, RebC, and AtmC mediate the degree of oxidation of chromopyrrolic acid on route to the natural products staurosporine, K252a, rebeccamycin, and AT2433-A1, respectively. shannon hay live oak bankWebDichlorochromopyrrolate synthase ( EC 1.21.3.9, RebD, dichlorochromopyrrolic acid synthase) is an enzyme with systematic name 2-imino-3- (7-chloroindol-3-yl)propanoate ammonia-lyase (dichlorochromopyrrolate-forming). [1] [2] This enzyme catalyses the following chemical reaction 4 2-imino-3- (7-chloroindol-3-yl)propanoate + O 2 shannon hayes care providers loungeWebAug 5, 2024 · Indolocarbazoles are biosynthesized through the successive modification of chromopyrrolic acid, a dimer of tryptophan. Furthermore, they are closely related to other groups of tryptophan derived natural products, most significantly the indolotryptolines. polyu onedrive businessWebChromopyrrolic Acid. Chromopyrrolic acid (55) formation is catalyzed by the chromopyrrolic acid synthase ClaD. From: The Alkaloids: Chemistry and Biology, … shannon hayes md